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Info selection procedure: Evaluate and info extraction ended up carried out according to the PRISMA flow diagrams. Two authors also reviewed entire texts from the content and extracted all the info independently.

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This methylation profile is by now obtained in the MBL stage3 and stays somewhat stable after some time. However, some CLL have intratumor variability in sure areas, which may alter the expression of quite a few genes and facilitate tumor evolution.71 Of Observe, this variability is bigger in U-CLL than in M-CLL and is also related to expanding variety of subclones.seven,71

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